Following ROC data was obtained during training of 159 proteins for predicting single
nucleotide and nucleotide steps using neural network. (SDCPred returns real values and binding information
is obtained at various cutoffs as in the following tables)
Overall single nucleotide-wise average ROC
| AUC of ROC (Ade) |
76.9% |
| AUC of ROC (Cyt) |
76.5% |
| AUC of ROC (Gua) |
77.4% |
| AUC of ROC (Thy) |
76.0% |
Detailed ROC Data:
| Cutoff |
Sensitivity (Ade) |
Specificity (Ade) |
Sensitivity (Cyt) |
Specificity (Cyt) |
Sensitivity (Gua) |
Specificity (Gua) |
Sensitivity (Thy) |
Specificity (Thy) |
| 0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
| 0.1 |
0.97 |
0.26 |
0.98 |
0.17 |
0.93 |
0.35 |
0.98 |
0.09 |
|
| 0.2 |
0.90 |
0.45 |
0.93 |
0.37 |
0.85 |
0.54 |
0.94 |
0.27 |
|
| 0.3 |
0.82 |
0.57 |
0.85 |
0.53 |
0.78 |
0.64 |
0.88 |
0.45 |
|
| 0.4 |
0.75 |
0.64 |
0.77 |
0.65 |
0.70 |
0.71 |
0.80 |
0.59 |
|
| 0.5 |
0.69 |
0.71 |
0.64 |
0.73 |
0.62 |
0.77 |
0.69 |
0.70 |
|
| 0.6 |
0.61 |
0.77 |
0.52 |
0.81 |
0.54 |
0.83 |
0.59 |
0.78 |
|
| 0.7 |
0.52 |
0.83 |
0.38 |
0.88 |
0.45 |
0.88 |
0.46 |
0.86 |
|
| 0.8 |
0.40 |
0.89 |
0.23 |
0.94 |
0.32 |
0.92 |
0.23 |
0.93 |
|
| 0.9 |
0.20 |
0.95 |
0.05 |
0.98 |
0.16 |
0.97 |
0.03 |
0.99 |
|
AUC of ROC for binding to Dinucleotide steps
| AUC of ROC (AA/TT) |
77.6% |
|
| AUC of ROC (AC/GT) |
77.3% |
|
| AUC of ROC (AG/CT) |
74.7% |
|
| AUC of ROC (AT/AT) |
75.3% |
|
| AUC of ROC (CA/TG) |
78.6% |
|
| AUC of ROC (CC/GG) |
75.9% |
|
| AUC of ROC (CG/CG) |
73.4% |
|
| AUC of ROC (GA/TC) |
75.6% |
|
| AUC of ROC (GC/GC) |
74.3% |
|
| AUC of ROC (TA/TA) |
78.8% |
|
Detailed ROC Data
| Cutoff |
Sensitivity (AA/TT) |
Specificity (AA/TT) |
Sensitivity (AC/GT) |
Specificity (AC/GT) |
Sensitivity (AG/CT) |
Specificity (AG/CT) |
Sensitivity (AT/AT) |
Specificity (AT/AT) |
Sensitivity (CA/TG) |
Specificity (CA/TG) |
Sensitivity (CC/GG) |
Specificity (CC/GG) |
Sensitivity (CG/CG) |
Specificity (CG/CG) |
Sensitivity (GA/TC) |
Specificity (GA/TC) |
Sensitivity (GC/GC) |
Specificity (GC/GC) |
Sensitivity (TA/TA) |
Specificity (TA/TA) |
| 0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
|
|
| 0.1 |
0.98 |
0.10 |
0.98 |
0.14 |
0.96 |
0.21 |
0.96 |
0.26 |
0.98 |
0.21 |
0.97 |
0.17 |
0.95 |
0.19 |
0.96 |
0.22 |
0.98 |
0.22 |
1 |
0.00 |
|
|
| 0.2 |
0.95 |
0.26 |
0.94 |
0.37 |
0.90 |
0.37 |
0.90 |
0.44 |
0.93 |
0.37 |
0.94 |
0.34 |
0.92 |
0.35 |
0.92 |
0.37 |
0.93 |
0.37 |
0.98 |
0.12 |
|
|
| 0.3 |
0.90 |
0.40 |
0.85 |
0.53 |
0.86 |
0.49 |
0.83 |
0.56 |
0.89 |
0.48 |
0.89 |
0.47 |
0.87 |
0.46 |
0.86 |
0.48 |
0.89 |
0.47 |
0.94 |
0.30 |
|
|
| 0.4 |
0.86 |
0.52 |
0.76 |
0.65 |
0.80 |
0.58 |
0.73 |
0.65 |
0.83 |
0.59 |
0.82 |
0.58 |
0.81 |
0.56 |
0.81 |
0.57 |
0.81 |
0.56 |
0.90 |
0.47 |
|
|
| 0.5 |
0.80 |
0.62 |
0.65 |
0.75 |
0.72 |
0.66 |
0.65 |
0.73 |
0.76 |
0.68 |
0.72 |
0.67 |
0.71 |
0.65 |
0.73 |
0.65 |
0.75 |
0.64 |
0.84 |
0.62 |
|
|
| 0.6 |
0.70 |
0.72 |
0.48 |
0.85 |
0.63 |
0.73 |
0.51 |
0.80 |
0.65 |
0.77 |
0.60 |
0.76 |
0.61 |
0.73 |
0.65 |
0.73 |
0.64 |
0.72 |
0.71 |
0.75 |
|
|
| 0.7 |
0.56 |
0.81 |
0.27 |
0.93 |
0.53 |
0.80 |
0.36 |
0.87 |
0.49 |
0.85 |
0.46 |
0.84 |
0.44 |
0.81 |
0.54 |
0.81 |
0.47 |
0.79 |
0.41 |
0.87 |
|
|
| 0.8 |
0.38 |
0.90 |
0.10 |
0.97 |
0.38 |
0.88 |
0.22 |
0.92 |
0.31 |
0.93 |
0.24 |
0.92 |
0.30 |
0.89 |
0.38 |
0.89 |
0.32 |
0.87 |
0.17 |
0.96 |
|
|
| 0.9 |
0.14 |
0.97 |
0.01 |
0.99 |
0.17 |
0.94 |
0.08 |
0.97 |
0.04 |
0.99 |
0.03 |
0.99 |
0.11 |
0.97 |
0.14 |
0.96 |
0.15 |
0.95 |
0.01 |
0.99 |
|
|